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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21580be7a430f3dff7b03e00fb112b8772ceb52182ba23e775b15cd737c172ff' 
  AND token = 'biNIVZfN+2rYDue1wJHiZVT/jOPcYrIMmR/JRxRnJIc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}