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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12e850eb91f293f697dd432f871a95611f3aae3d4e3cdaf25dd60671e3f24132' 
  AND token = 'cIbJD9pRVqKGnxTbMPnSZOGzZwx2E+sUCWf48Tu9qtI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}