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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22f3469b4c98d2b946dc1c3fad65641b42857ab8f0308d651c3845fd13e96ad5' 
  AND token = '2t1oiMjCzIHc+zZ6aaRcXPMzZ0LIxH0+UYzv2r5wO4o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}