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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f3a961290b818ccf76b352e28dd834e9750e98c3421afd73a82e13c740aec112' 
  AND token = 'yK5s5Z8KWKPBniLS1nen/oDkayx5cdzbEBxPjpWtQSI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}