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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8bb0efe43ff394f8d0fcfdf99d44a72e60758aa35f55fed2a72fc896af052210' 
  AND token = 'aMhbGh5sFHmLl05aUwbtwYuFLW3SEhL2pP+uUc5pwNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}