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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280e918c07244939f076904da426e650e2208193120fd9fab84f0a71447c8282' 
  AND token = 'rENyrYT4hQXUOvZuv8fYe+PSo0iadqoBtCQYeut3XtY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}