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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '396d46f0a84dd2dd77b3a2141ecb010ea844d27b395f0bf6bfa6dd8f3b71bb03' 
  AND token = 'QRZddLpMLnJoWOkT1WmT5G4JApIdkG7xWfRTXbik4WM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}