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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c77fd2c37fcbd367ab01e55870d61d342ee3d96204a416942a78a4d1d878c59' 
  AND token = '6WK71IO2mhs4Y3GuP7X4DCdrlZR+MiPNWaVKO/vfDqc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}