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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5da68cc8ddc5cf68689dda048da4e2fb99fb6b7e9b922e4276f182648bcb366f' 
  AND token = 'ya5eBS+/qoJIcdvEEbbFm4bIHN60IRZqo3+m+EC/anw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}