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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45f0f254ab1b94586905825aef730f39a491e2d5ce4f5d7511380152d9312290' 
  AND token = 'YMitNwF4TLa1D+1Y8s/5v00VOsK9VltuvwR5LCVzZhc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}