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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd422ea0f6fb3f38bd61c7b5466d387e8a13111f03a221457fad9aa0d2ba612cc' 
  AND token = 'mV4jYRiw6lWmeIM9SDXXytcSwRF3cmtkxQgRZBd3xzE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}