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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '39a0b50e8d1cde94ee5dca1804f5b5c66a8ba949a84e77b9bde3f648199392a9' 
  AND token = '43WDmlX/qyq/PA3vD0EhGEbhY2k80FaDkB7eHtkHHSY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}