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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59a21c606c39a43e47b16ef9b996933942a23f57a48206c83157547488af3504' 
  AND token = 'x/sURK8uxe8XGr3SoWNeH7glieMCVekQITnI07w5Oi0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}