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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '376d649cc0fd394f24d78291d92e095529f1c6dceef6a42a2c92f685c723a3d6' 
  AND token = '8A4tTJIoCFxDnWGMfPHoU2f+Bt+Ma9DFV194ywERIUM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}