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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0cc946f5e5b97916d7dde17f62162e846bead3cfd2bb68c46105f522b3bea300' 
  AND token = 'o4u1Ql5u3eMNO83p327fltYwuUw2R3UUS2/eNKAys7I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}