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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b1d18017d25ba58210da0ecaf5b9b6dc423f1f78c1fcdbd4e6c01bc953008287' 
  AND token = 'yyFtBxLmqdR+U1LRdQZjrKuqhIBImdnz8JSO8vXSZ58=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}