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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a321f2eca8db884f33663540cab072fb2181391a1a8b6d2cb43b8365c4f40a00' 
  AND token = 'FivrRnrLqrHCxIl4P18xr/uHfECfXqW7SJ3ipSIEgdY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}