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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '187ac219b52b0fd784eb2382a058c8015a37311df484d4af998bdc34e0674242' 
  AND token = 'e0h9Cnb0Mf+UfVbY2jx0FkNy+RBqIaOL2WUM1zww0dQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}