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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c8317fbd48d4f43b1c3f5cac2c365e8581758d115674d44f11b70da8a036446' 
  AND token = '2434FO3etAtiD3W69+pK4eocXdXM2xFDCwxCWk2lzNE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}