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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4bc9649b21b1ea7940457a79414fbb71e4cd8801b147f9b69cdbc1cb2af39421' 
  AND token = 'tEt5J4t2/Zm6JGsy7IHX4MjfIMu+3PmepWE39OpmJko=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}