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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af7296a49804e77a220c00d294ae3bfeab30a7d399cc9b29da10c7603f4886e6' 
  AND token = 'MHyZVwLDJCQ+B7CxkK6hmZM7oFAWUJ8xl4q44lLMa90=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}