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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c81543ffed7ee3c68a749f95e506dd0f5d4ce71b0b2fc6b1e2ffc4967a653309' 
  AND token = 'TaHQu7dWBCs6t2yZcPzxgm0zX2mAI4H4I2oPc0KmxTI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}