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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f75cf428f63b14ad8363a812be7f47027a26532d4228196d6c92301bf008e12' 
  AND token = 'FD4t+5gu2+FW/UyeSZF/q6/MySSUhoCCsf66mrTJ9m0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}