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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '330df7b38ef47b52b9fc570589ab8912817540a722839da45890e1df80ee1018' 
  AND token = 'rUg6t/yqClSsLa7SVhA7yZZlY8vkL/XYuLKbMMHlYvM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}