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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18a66306df41646866cd32276c160b028d001db00cd87afd4bd52f2c20f0561a' 
  AND token = 'z/NIO8NTJKri2ulBD+zD5s1ODw3wxlft7qCDIXuNhPw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}