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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21d850da0285f19fb984a3120a932b165d0a1c375c30bb98739a0fdc87bdd339' 
  AND token = 'hoPdQHYN9m/bK7xRh6hwEPa4qsrnTaZePI7Ql4xH4lw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}