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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '022202162d22f9ff70eb44300d39e9a3bc426238788c097b79643e3a5bd15fc1' 
  AND token = '2HSGnMuqKnXqa4s0ReLPEa/hWOt7lh0VCBUWq3N6uOw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}