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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8d529e3bfbedc028f9199756cf2f62130d94a535c922f866f07c843b6bdd10c' 
  AND token = '22BjglkBETWpFkKQdBCdxuMLNSuKe+0A63HbMZEW2VM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}