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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '73a74a607a3d7b3a77d34ecae64df2657c1a130893dd0d010c5c88f0a860d810' 
  AND token = 'LZFpUWLVKLKkKts/K6wgb8vf4qCbkbijC9qIjPMIzPk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}