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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8448a0aedc232925d7c1071e6e245fe2f3373ad73c9680f708af22caea771f9a' 
  AND token = '3+7zklDxid/jm45511AP+tsSC0PyeeHmCapXSvEIlSY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}